DDD85646

DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis.


Cat. No.: EX-A9381	Purity: >98%

	Chemical structure of DDD85646

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	750	In-stock
500mg	1050	In-stock
1g	1650	In-stock
5g	4850	In-stock
10g	7450	In-stock

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Synonyms	IMP 366
Synonyms 2	PCLX 002
CAS No.	1215010-55-1
Purity	>98%
Formula	C21H24Cl2N6O2S
Mol Weight	495.425
Appearance	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Spinks D, et al. Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode. ChemMedChem. 2015;10(11):1821-1836. [2]. Kallemeijn WW, et al. Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases. Cell Chem Biol. 2019;26(6):892-900.e4. [3]. Frearson JA, et al. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature. 2010;464(7289):728-732. [4]. Paape D, et al. Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes. PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3363.
CoA	CoA of DDD85646

Smiles:	ClC1=CC(C2=CC=NC(N3CCNCC3)=C2)=CC(Cl)=C1S(NC4=C(C)N(C)N=C4C)(=O)=O


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