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Product Information:

VH-298

VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM, used in PROTAC technology.

Cat. No.: EX-A1505    Purity: >98%
VH-298
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg425In-stock
100mg600In-stock
250mg900In-stock
500mg1200In-stock
1g1800In-stock
5g6200In-stock


CAS No.2097381-85-4
Purity>98%
FormulaC27H33N5O4S
Mol Weight523.647
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312.

CoACoA of VH-298
Smiles:CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(CC2)C#N)C(C)(C)C)C=C1

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