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Product Information:

JND3229

JND3229 is a new highly potent EGFR(C797S) inhibitor with IC50 values of 5.8nM, 30.5nM and 6.8nM for EGFR (L858R/T790M/C797S), EGFR (T790M, L858R) and EGFR, respectively.

Cat. No.: EX-A3320    Purity: >98%
JND3229
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg550In-stock
50mg750In-stock
100mg1050In-stock
250mg1950In-stock
1g3900Inquire
5g14500Inquire


CAS No.2260886-64-2
Purity>98%
FormulaC33H41ClN8O2
Mol Weight617.184
AppearanceSolid powder
SolubilityDMSO >10mg/mL (Need ultrasonic)
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Lu X, et al. Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy. ACS Med Chem Lett. 2018 Oct 8;9(11):1123-1127.
CoACoA of JND3229
Smiles:CCC(=O)NC1CCC(CC1)N2C3=NC(=NC=C3CN(C2=O)C4=CC=CC=C4Cl)NC5=CC(=C(C=C5)N6CCN(CC6)C)C

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