Danicopan

Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).


Cat. No.: EX-A3068	Purity: 99.99%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	395	In-stock
100mg	495	In-stock
250mg	850	In-stock
500mg	1150	In-stock

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Synonyms	ACH-4471
CAS No.	1903768-17-1
Purity	99.99%
Formula	C26H23BrFN7O3
Mol Weight	580.408
Appearance	white solid powder
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yuan X, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475.
CoA	CoA of Danicopan
HNMR	HNMR of Danicopan
HPLC/LC-MS	LCMS/HPLC of Danicopan

Smiles:	CC1=NC=C(C=N1)C2=CC3=C(C=C2)N(N=C3C(=O)C)CC(=O)N4C[C@@H](C[C@H]4C(=O)NC5=NC(=CC=C5)Br)F


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