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Product Information:

Danicopan

Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

Cat. No.: EX-A3068    Purity: 99.99%
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg325In-stock
100mg465In-stock
250mg765In-stock
500mg1050In-stock
1g1650In-stock


SynonymsACH-4471
CAS No.1903768-17-1
Purity99.99%
FormulaC26H23BrFN7O3
Mol Weight580.408
Appearancewhite solid powder
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Yuan X, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475.
CoACoA of Danicopan
HNMRHNMR of Danicopan
HPLC/LC-MSLCMS/HPLC of Danicopan
Smiles:CC1=NC=C(C=N1)C2=CC3=C(C=C2)N(N=C3C(=O)C)CC(=O)N4C[C@@H](C[C@H]4C(=O)NC5=NC(=CC=C5)Br)F