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Product Information:

AG-270

AG-270 is an allosteric, noncompetitive, first-in-class, reversible and orally active MAT2A inhibitor, with an IC50 of 14 nM.

Cat. No.: EX-A5019    Purity: >98%
AG-270
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg600In-stock
250mg900In-stock
500mg1400In-stock
1g2550In-stock
5g7850In-stock
10g12800In-stock


SynonymsAG270
CAS No.2201056-66-6
Purity>98%
FormulaC30H27N5O2
Mol Weight489.5677
AppearanceSolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Zenon Konteatis, et al. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J Med Chem. 2021 Apr 8.

[2]. Marc L Hyer, et al. The MAT2A inhibitor AG-270 combines with both taxanes and gemcitabine to yield enhanced antitumor activity in patient-derived xenograft models.
CoACoA of AG-270

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