ERD-3111

ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC50: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model.


Cat. No.: EX-A9186	Purity: >98%

	Chemical structure of ERD-3111

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	800	In-stock
25mg	1660	In-stock
50mg	get quote	In-stock
100mg	2880	In-stock
500mg	get quote	In-stock
1g	get quote	In-stock

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CAS No.	2832865-25-3
Purity	>98%
Formula	C45H46F4N8O5
Mol Weight	854.891
Appearance	solid
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chen Z, et al. Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity. J Med Chem. 2023 Aug 30.
CoA	CoA of ERD-3111

Smiles:	FC(CN1[C@@H](CC2=C([C@H]1C3=C(C=C(C=C3F)N4CCC5(CC4)CCN(C(CN6CC(C=C(C7=C8)C(N(C7=O)C9CCC(NC9=O)=O)=O)=C8C6)=O)CC5)F)C=CC%10=C2C=NN%10)C)F


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