BKN-1

BKN-1 is a bifunctional ligand that can not only track the formation of mtG4s (G-quadruplexes, four-stranded DNA structures containing Hoogsteen bonds) through far-red emission, but can also induce mitochondrial dysfunction. BKN-1 has anti-tumor activity and may cause mtDNA loss, damage mitochondrial integrity, reduce ATP levels, and trigger ROS imbalance, leading to apoptosis and autophagy.


Cat. No.: EX-A8923	Purity: >98%

	Chemical structure of BKN-1

For research only, Do not use for Human!

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CAS No.	1607831-82-2
Purity	>98%
Formula	C31H29IN2
Mol Weight	556.4798

Reference:	[1]. Wang Z, et al. Discovery of a far-red carbazole-benzoindolium fluorescent ligand that selectively targets mitochondrial DNA and suppresses breast cancer growth. Eur J Med Chem. 2024 Jan 15;264:116046.
CoA	CoA of BKN-1

Smiles:	CCN1C2=C(C=C(/C=C/C3=[N+](C)C(C=CC4=C5C=CC=C4)=C5C3(C)C)C=C2)C6=C1C=CC=C6.[I-]


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