GW5074

GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms.


Cat. No.: EX-A889	Purity: >98%

	Chemical structure of GW5074

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	325	In-stock
250mg	500	In-stock
500mg	700	In-stock
1g	1050	In-stock
2g	1600	In-stock
5g	3300	In-stock

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CAS No.	220904-83-6
Purity	>98%
Formula	C15H8Br2INO2
Mol Weight	520.942
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chin PC, et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem, 2004, 90(3), 595-608. [2]. Lei Y, et al. The Raf-1 inhibitor GW5074 and NSC 34521 suppress sidestream smoke-induced airway hyperresponsiveness in mice. Respir Res, 2008, 9(1), 71.
CoA	CoA of GW5074

Smiles:	OC1=C(Br)C=C(\C=C2/C(=O)NC3=C2C=C(I)C=C3)C=C1Br


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