RNK-05047

RNK-05047 is a PROTAC degrader of BRD4 which displays significant tumor growth inhibition in tumor -bearing xenograft models in mice and can be used for anticancer research.


Cat. No.: EX-A8855	Purity: >98%

	Chemical structure of RNK-05047

For research only, Do not use for Human!

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CAS No.	2503036-46-0
Purity	>98%
Formula	C47H54Cl2N10O4S
Mol Weight	925.967
Appearance	powder
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Shi Y, Liao Y, Liu Q, et al. BRD4-targeting PROTAC as a unique tool to study biomolecular condensates. Cell Discov. 2023;9(1):47. Published 2023 May 9. doi:10.1038/s41421-023-00544-0 [2]. Schwalm MP, Knapp S. BET bromodomain inhibitors. Curr Opin Chem Biol. 2022;68:102148. doi:10.1016/j.cbpa.2022.102148 [3]. Hu Z, Crews CM. Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic. Chembiochem. 2022;23(2):e202100270. doi:10.1002/cbic.202100270 [4]. Maneiro MA, Forte N, Shchepinova MM, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020;15(6):1306-1312. doi:10.1021/acschembio.0c00285 [5]. Gadd MS, Testa A, Lucas X, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017;13(5):514-521. doi:10.1038/nchembio.2329
CoA	CoA of RNK-05047

Smiles:	CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N4CCC(CC4)CN5CCN(CC5)CC6=CC=C(N7C(C8=CC(C(C)C)=C(C=C8O)O)=NNC7=O)C=C6)=O)C9=NN=C(C)N29.[H]Cl


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