FDW028

FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research .


Cat. No.: EX-A8663	Purity: >98%

	Chemical structure of FDW028

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	685	In-stock
100mg	900	In-stock
200mg	1600	In-stock
500mg	get quote	In-stock
1g	get quote	In-stock
2g	get quote	Inquire

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CAS No.	2768426-49-7
Purity	>98%
Formula	C22H24N6O
Mol Weight	388.4656
Appearance	white to off-white powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wang M, et al. FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer. Cell Death Dis. 2023 Aug 3;14(8):495.
CoA	CoA of FDW028

Smiles:	OC1=CC(CNCC2=CC=CC=C2)=NC3=NC(NCC4=CC=C(CC)C=C4)=NN31


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