NRX-0492

NRX-0492 is an orally active and potent degrader of BTK. NRX-0492 catalyzes ubiquitylation and proteasomal degradation of BTK with DC50≤0.2 nM and DC90≤0.5 nM, respectively. NRX-0492 inhibits B-cell receptor (BCR)-mediated signaling, transcriptional programs, and chemokine secretion. Moreover, NRX-0492 also links a noncovalent BTK-binding domain to Cereblon.


Cat. No.: EX-A7960	Purity: 98+%

	Chemical structure of NRX-0492

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	1485	In-stock
500mg	2285	In-stock
1g	3325	In-stock
2g	4990	In-stock
5g	get quote	In-stock
10g	get quote	In-stock

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CAS No.	2416130-57-7
Purity	98+%
Formula	C43H51N11O6
Mol Weight	817.9351
Appearance	Light yellow to yellow solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang D, et al. NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. Blood. 2023 Mar 30;141(13):1584-1596.
Data Sheet	Data sheet of NRX-0492
CoA	CoA of NRX-0492
SDS	SDS of NRX-0492


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