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Product Information:

HRO761

HRO761 is a potent, selective, allosteric WRN inhibitor that binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation.

Cat. No.: EX-A7900A    Purity: >98%
Chemical
Chemical structure of HRO761


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg1150In-stock
1g1800In-stock
2gget quoteIn-stock
3gget quoteIn-stock
5g6500In-stock
10gget quoteIn-stock


SynonymsWerner syndrome RecQ helicase-IN-1
CAS No.2869954-34-5
Purity>98%
FormulaC31H31ClF3N9O5
Mol Weight702.083
Appearancesolid powder
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Ferretti S, Hamon J, de Kanter R, et al. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Nature. Published online April 24, 2024. doi:10.1038/s41586-024-07350-y

[2]. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060

CoACoA of HRO761

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