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Product Information:

Onatasertib

CC-223 (ATG-008, Onatasertib), is an orally available inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor CC-223 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation.

Cat. No.: EX-A781    Purity: >98%
Chemical
Chemical structure of Onatasertib


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg865In-stock
1g1250In-stock
2g2300In-stock
3gget quoteIn-stock
5gget quoteIn-stock
10gget quoteIn-stock


SynonymsCC-223
Synonyms 2ATG-008
CAS No.1228013-30-6
Purity>98%
FormulaC21H27N5O3
Mol Weight397.4708
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Bendell JC, et al. A phase I dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or multiple myeloma. Cancer. 2015 Oct 1;121(19):3481-90.

[2]. Mortensen DS, et al. Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223. J Med Chem. 2015 Jul 9;58(13):5323-33.

[3]. Mortensen DS, et al. CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization. Mol Cancer Ther. 2015 Jun;14(6):1295-305.

[4]. Ashworth RE, et al. Mammalian target of rapamycin inhibition in hepatocellular carcinoma. World J Hepatol. 2014 Nov 27;6(11):776-82.

CoACoA of Onatasertib
Smiles:CO[C@H]1CC[C@@H](CC1)N1C(=O)CNC2=NC=C(N=C12)C1=CC=C(N=C1)C(C)(C)O

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