background


Product Information:

G007-LK

G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS1/2, respectively. G007-LK displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice.

Cat. No.: EX-A656    Purity: >98%
Chemical
Chemical structure of G007-LK


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg1550In-stock
1g3000Inquire
2g4800Inquire
5g8000Inquire


CAS No.1380672-07-0
Purity>98%
FormulaC25H16ClN7O3S
Mol Weight529.958
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Voronkov A, et al. Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor. J Med Chem, 2013, 56(7), 3012-3023.

[2]. Lau T, et al. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res, 2013, 73(10), 3132-3144.
CoACoA of G007-LK
Smiles:CS(=O)(=O)C1=CN=C(C=C1)C1=NN=C(\C=C\C2=NN=C(O2)C2=CC=C(C=C2)C#N)N1C1=CC=CC=C1Cl

KEYWORDS: buy G007-LK | G007-LK supplier | purchase | cost | manufacturer | order | distributor | buy 1380672-07-0 | 1380672-07-0 supplier