Milademetan

Milademetan (DS-3032) is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) induces G1 cell cycle arrest, senescence and apoptosis.


Cat. No.: EX-A6155	Purity: >98%

	Chemical structure of Milademetan

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	1250	In-stock
250mg	2400	In-stock
500mg	3900	In-stock
1g	get quote	In-stock
2g	get quote	In-stock
5g	get quote

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Synonyms	DS-3032
CAS No.	1398568-47-2
Purity	>98%
Formula	C30H34Cl2FN5O4
Mol Weight	618.526
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. ARYL SULFONOHYDRAZIDES. WO 2017069289 A1. [2]. M.M. Gounder, et al. Milademetan, an oral MDM2 inhibitor, in well-differentiated/dedifferentiated liposarcoma: results from a phase 1 study in patients with solid tumors or lymphomas. European Journal of Cancer 138S2 (2020) S1–S62. [3]. Li, Yangbing, et al. Development of novel PROTAC Small-Molecule Degraders of MDM2 Protein and Peptidomimetic Inhibitors Targeting WDR5-MLL1 Protein-Protein Interaction. [4]. Viktor Arnhold, et al. Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma. ncotarget. 2018 Jan 5; 9(2): 2304–2319.
CoA	CoA of Milademetan


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