ASP2453

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.


Cat. No.: EX-A6116	Purity: >98%

	Chemical structure of ASP2453

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	550	In-stock
10mg	785	In-stock
25mg	1285	In-stock
50mg	2085	In-stock
100mg	3500	In-stock
500mg	get quote	In-stock

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CAS No.	2241719-73-1
Purity	>98%
Formula	C40H48F3N7O4
Mol Weight	747.8488
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.
CoA	CoA of ASP2453


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