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Product Information:

ARQ-751

Vevorisertib (MK-4440, ARQ 751) is a novel potent, selective, allosteric pan-AKT inhibitor with IC50 of 0.55 nM, 0.81 nM and 1.31 nM for AKT1, 2 and 3, respectively.

Cat. No.: EX-A5803    Purity: >98%
Chemical
Chemical structure of ARQ-751


For research only, Do not use for Human!

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SynonymsVevorisertib
Synonyms 2MK-4440
CAS No.1416775-46-6
Purity>98%
FormulaC35H38N8O
Mol Weight586.7292
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. ArQule Presents Recent Data on ARQ 751 at the 2019 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.

[2]. Vevorisertib (ARQ 751) (4440-001) as a Single Agent or in Combination With Other Anti-Cancer Agents, in Solid Tumors With PIK3CA / AKT / PTEN Mutations.

[3]. Abstract A034: The use of biomarkers and ctDNA in a phase 1 trial of ARQ 751

CoACoA of ARQ-751

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