Bemnifosbuvir

Bemnifosbuvir is a potent and orally active HCV viral replication inhibitor. AT-511 is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM).


Cat. No.: EX-A5388	Purity: >98%

	Chemical structure of Bemnifosbuvir

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	400	In-stock
100mg	600	In-stock
200mg	900	In-stock
500mg	1500	In-stock
1g	2550	In-stock
5g	get quote	In-stock

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Synonyms	AT-511
CAS No.	1998705-64-8
Purity	>98%
Formula	C24H33FN7O7P
Mol Weight	581.5337
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Steven S Good, et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15(1):e0227104. [2]. Steven S Good, et al. AT-527, a double prodrug of a guanosine nucleotide analog, is a potent inhibitor of SARS-CoV-2 in vitro and a promising oral antiviral for treatment of COVID-19. Antimicrob Agents Chemother. 2021 Feb 8;AAC.02479-20. [3]. Elina Berliba, et al. Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis. Antimicrob Agents Chemother. 2019 Sep 30;63(12):e01201-19.
CoA	CoA of Bemnifosbuvir

Smiles:	O[C@H]1[C@](F)(C)[C@H](N2C3=NC(N)=NC(NC)=C3N=C2)O[C@@H]1CO[P@](OC4=CC=CC=C4)(N[C@@H](C)C(OC(C)C)=O)=O


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