ALC-0315

ALC-0315 is a synthetic cationic lipid (or ionizable lipid). A colorless oily material, it has attracted attention as a component of the SARS-CoV-2 vaccine, BNT162b2, from BioNTech and Pfizer. Specifically, it is one of four components that form lipid nanoparticles (LNPs), which encapsulate and protect the otherwise fragile mRNA that is the active ingredient in these drugs. These nanoparticles promote the uptake of therapeutically effective nucleic acids such as oligonucleotides or mRNA both in vitro and in vivo.


Cat. No.: EX-A5120	Purity: >98%

	Chemical structure of ALC-0315

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	785	In-stock
500mg	985	In-stock
1g	1285	In-stock
5g	4500	In-stock

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CAS No.	2036272-55-4
Purity	>98%
Formula	C48H95NO5
Mol Weight	766.2716
Appearance	colourless to light yellow oil
Solubility	Soluble in DMSO, DCM, DMF
Shelf Life	>2 years if stored properly
Storage	Pure form -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Moghimi SM. Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines. Mol Ther. 2021;29(3):898-900.
CoA	CoA of ALC-0315

Smiles:	OCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O


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