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Product Information:

SAR407899

SAR407899 is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

Cat. No.: EX-A4141    Purity: >98%
Chemical
Chemical structure of SAR407899


For research only, Do not use for Human!

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SynonymsSAR-407899
CAS No.923359-38-0
Purity>98%
FormulaC14H16N2O2
Mol Weight244.289
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Matthias Löhn, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83.

[2]. Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59.
CoACoA of SAR407899
Smiles:O=C(NC=C1)C(C1=C2)=CC=C2OC3CCNCC3

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