Vacuolin-1

Vacuolin-1, a potent and cell-permeable inhibitor of lysosomal exocytosis, that blocks the Ca 2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. Vacuolin-1 is also a potent and selective PIKfyve inhibitor, and inhibits late‐stage autophagy by impairing lysosomal maturation.


Cat. No.: EX-A4125	Purity: >98%

	Chemical structure of Vacuolin-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	350	In-stock
500mg	500	In-stock
1g	765	In-stock
2g	1250	In-stock
5g	2850	In-stock
10g	4450	In-stock

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CAS No.	351986-85-1
Purity	>98%
Formula	C26H24IN7O
Mol Weight	577.4195
Appearance	solid powder
Solubility	Soluble in DMSO, not in water
Shelf Life	>2 years if stored properly
Storage	-20℃, stored under nitrogen
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jan Cerny, et al.The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 2004 Sep;5(9):883-8. [2]. Osamu Sano, et al. Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett. 2016 Jun;590(11):1576-85. [3]. Yingying Lu, et al. Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A. Autophagy
CoA	CoA of Vacuolin-1

Smiles:	IC1=CC(/C=N/NC2=NC(N(C3=CC=CC=C3)C4=CC=CC=C4)=NC(N5CCOCC5)=N2)=CC=C1


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