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Product Information:

TAK-981

TAK-981 is a selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities.

Cat. No.: EX-A3291    Purity: >98%
Chemical
Chemical structure of TAK-981


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg1150In-stock
500mg1950In-stock
1g2850In-stock
2gGet quoteIn-stock
5gGet quoteIn-stock


CAS No.1858276-04-6
Purity>98%
FormulaC25H28ClN5O5S2
Mol Weight578.103
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Mithun Khattar, et al. TAK-981: A first in class SUMO inhibitor in Phase 1 trials that promotes dendritic cell activation, antigen-presentation, and T cell priming. Cancer Res 2019;79(13 Suppl):Abstract nr 3252.

[2]. Allison J. Berger, et al. Pharmacodynamic evaluation of the novel SUMOylation inhibitor TAK-981 in a mouse tumor model. Cancer Res 2019;79(13 Suppl):Abstract nr 3079.
CoACoA of TAK-981
Smiles:O=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=NC=NC=C2C(C3=CC([C@@H]4NCCC5=C4C=C(Cl)C=C5)=C(C)S3)=O)C1)(N)=O

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