VH032-NH2

(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.


Cat. No.: EX-A2835	Purity: >98%

	Chemical structure of VH032-NH2

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1g	600	In-stock
5g	950	In-stock
10g	1550	In-stock
25g	2550	In-stock
50g	Get quote	In-stock
100g	Get quote	In-stock

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Synonyms	(S,R,S)-AHPC
Synonyms 2	VHL ligand 1
CAS No.	1448297-52-6
Purity	>98%
Formula	C22H30N4O3S
Mol Weight	430.564
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.
CoA	CoA of VH032-NH2

Smiles:	CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)C=C1


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