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Product Information:

Fulacimstat

Fulacimstat is an orally available chymase inhibitor, with IC50s of 4, 3 nM for human and hamster chymase enzyme, respectively.

Cat. No.: EX-A2732    Purity: >98%
Chemical
Chemical structure of Fulacimstat


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg790In-stock
250mg1550In-stock
1g3100In-stock


SynonymsBAY1142524
CAS No.1488354-15-9
Purity>98%
FormulaC23H16F3N3O6
Mol Weight487.3848
Appearanceoff-white powder
SolubilitySoluble in DMSO, not in water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Hanna Tinel, et al. Abstract 13624: A Novel Chymase Inhibitor BAY 1142524 Reduces Fibrosis and Improves Cardiac Function After Myocardial Infarction in Hamster. Circulation. 2018;136:A13624.

[2]. Kanefendt F, et al. Pharmacokinetics, Safety, and Tolerability of the Novel Chymase Inhibitor BAY 1142524 in Healthy Male Volunteers. Clin Pharmacol Drug Dev. 2018 Jun 7.
CoACoA of Fulacimstat
Smiles:CN1C(=O)OC2=CC(=CC=C12)N1C=C(C(O)=O)C(=O)N([C@@H]2CCC3=C(C=CC=C23)C(F)(F)F)C1=O

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