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Product Information:

Perifosine

Perifosine is an oral Akt inhibitor which inhibits proliferation of different tumor cell lines with IC50s of 0.6-8.9 μM.

Cat. No.: EX-A2229    Purity: >98%
Perifosine
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1g490In-stock
5g1100In-stock
10g1760In-stock


SynonymsKRX-0401
Synonyms 2NSC 639966
CAS No.157716-52-4
Purity>98%
FormulaC25H52NO4P
Mol Weight461.6584
Appearancesolid powder
SolubilitySoluble in H2O
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Momota H, et al. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res, 2005, 65(16), 7429-7435.

[2]. Vyomesh Patel, et al. Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Res, 2002, 62(5), 14

[3]. Chen L, et al. Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures. Epilepsia. 2012 Nov;53(11):2026-33.

CoACoA of Perifosine
Smiles:CCCCCCCCCCCCCCCCCCOP([O-])(=O)OC1CC[N+](C)(C)CC1

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