Glecaprevir

Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. Glecaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 4.09 μM.


Cat. No.: EX-A1940	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	400	In-stock
250mg	600	In-stock
500mg	900	In-stock
1g	1450	In-stock
5g	4500	In-stock
10g	6800	In-stock

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Synonyms	ABT-493
CAS No.	1365970-03-1
Purity	>98%
Formula	C38H46F4N6O9S
Mol Weight	838.865
Appearance	White to off-white solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ng TI, et al. In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir. Antimicrob Agents Chemother. 2017 Oct 30. pii: AAC.01620-17. [2]. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
CoA	CoA of Glecaprevir

Smiles:	[H][C@@]12C[C@H](N(C1)C(=O)[C@@H](NC(=O)O[C@]1([H])CCC[C@@]1([H])OC\C=C\C(F)(F)C1=NC3=CC=CC=C3N=C1O2)C(C)(C)C)C(=O)N[C@@]1(C[C@H]1C(F)F)C(=O)NS(=O)(=O)C1(C)CC1


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