E7449

Stenoparib (E7449) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ∼50 and ∼50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.


Cat. No.: EX-A1282	Purity: >98%

	Chemical structure of E7449

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	300	In-stock
100mg	400	In-stock
250mg	600	In-stock
500mg	900	In-stock
1g	1350	In-stock
5g	4050	In-stock

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Synonyms	Stenoparib
Synonyms 2	2X-121
CAS No.	1140964-99-3
Purity	>98%
Formula	C18H15N5O
Mol Weight	317.3446
Appearance	Off-white solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. McGonigle S, et al. E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling. Oncotarget. 2015 Dec 1;6(38):41307-23.
CoA	CoA of E7449

Smiles:	O=C1NNC2=C3C(C=CC=C13)=NC(CN1CC3=C(C1)C=CC=C3)=N2


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