AD1058

AD1058 is an orally active, selective, and blood-brain barrier permeable inhibitor of ATR. AD1058 exhibits in vivo anticancer activity, inhibiting cell proliferation, disrupting the cell cycle, and inducing Apoptosis. AD1058 can be utilized in research on brain and central nervous system metastases stemming from advanced solid tumors.


Cat. No.: EX-A11483	Purity: >98%

	Chemical structure of AD1058

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
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25mg	get quote	Inquire
50mg	685	Inquire
100mg	900	Inquire
500mg	get quote	Inquire
1g	get quote	Inquire

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CAS No.	2907782-78-7
Purity	>98%
Formula	C19H20N6O3S
Mol Weight	412.465
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Liu Z, Jiang K, et al. Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies. J Med Chem. 2024 Aug 8;67(15):12735-12759.
CoA	CoA of AD1058

Smiles:	C[C@H]1N(C2=C3C(=NC(=N2)C4=C5C(=NC=C4)NC=C5)N(S(C)(=O)=O)C=C3)CCOC1


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