PROTAC IRAK4 degrader-1

PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively.


Cat. No.: EX-A11414	Purity: >98%

	Chemical structure of PROTAC IRAK4 degrader-1

For research only, Do not use for Human!

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CAS No.	2360533-90-8
Purity	>98%
Formula	C44H39F3N12O7
Mol Weight	904.8519

Reference:	[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.
CoA	CoA of PROTAC IRAK4 degrader-1

Smiles:	O=C(C1=CC=C(N2C=C(NC(C3=COC(C4=CC=NC(NCC5CC5)=C4)=N3)=O)C(C(F)(F)F)=N2)C=C1)NCCCN(C=N6)C=C6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7


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