SBI-810

SBI-810 is a functional selective β-arrestin-biased allosteric modulator of the neurotensin receptor 1 (NTSR1). In the presence of the endogenous ligand neurotensin (NT), SBI-810 regulates NTSR1 signaling through a G protein-specific mechanism. It fully antagonizes NT-induced Gq activation and partially antagonizes NT-induced Gi1 activation, allowing NTSR1 to activate GoA and G12.


Cat. No.: EX-A10158	Purity: >98%

	Chemical structure of SBI-810

For research only, Do not use for Human!

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250mg	1292	Inquire
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Synonyms	SBI 810
Synonyms 2	SBI810
CAS No.	1849603-79-7
Purity	>98%
Formula	C27H34N4O2
Mol Weight	446.5845
Appearance	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Guo, Ran et al. “Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.” Cell, S0092-8674(25)00508-2. 15 May. 2025, doi:10.1016/j.cell.2025.04.038
CoA	CoA of SBI-810

Smiles:	OCCN(C=1C=CC=2N=C(N=C(C2C1)N3CCC(C=4C=CC=CC4OC)CC3)C5(C)CC5)C


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