Org 274179-0

Org 274179-0 is a highly potent, allosteric antagonist of the thyroid-stimulating hormone receptor (TSH receptor), inhibits bTSH-, hTSH- and M22-mediated CRE-luciferase transactivation in the CHO cell line.


Cat. No.: EX-A10144	Purity: >98%

	Chemical structure of Org 274179-0

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	646	In-stock
50mg	972	In-stock
100mg	1496	In-stock
250mg	2254	In-stock
500mg	get quote	In-stock
1g	get quote	In-stock

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Synonyms	Org274179-0
CAS No.	1421683-12-6
Purity	>98%
Formula	C28H27F3N2O2
Mol Weight	480.5214
Appearance	solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. van Koppen, Chris J et al. “Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptor.” British journal of pharmacology vol. 165,7 (2012): 2314-24. doi:10.1111/j.1476-5381.2011.01709.x
CoA	CoA of Org 274179-0

Smiles:	C[C@@]1(C=2C(N(C(C)=O)CC1)=CC=C(NC(CCC3=CC(C(F)(F)F)=CC=C3)=O)C2)C4=CC=CC=C4


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