ZX782

ZX782 is a HyT GPX4 degrader and a ferroptosis inducer, which induces GPX4 degradation and significantly increases lipid ROS accumulation in HT1080 cells. ZX782 can be used to treat AD by reducing the size and/or number of brain amyloid plaques and by inhibiting the spread of IL-1beta-positive microglial-like cells around amyloid plaques. ZX782 is labeled with hydrophobic benzyl alcohol (HBA) and appears bright blue under acidic conditions, which can be used for quantitative determination. ZX782 is composed of target protein ligand (red part) ML-210, PROTAC linker (black part) Bromo-PEG2-CH2-Boc and Hty molecule (blue part) Adamantan-1-ylmethanamine. The conjugate consisting of Hyt and linker parts is Adamantan-C-amide-PEG2-C-Br, and the activity control of the target protein ligand is Hydroxyl-ML-210.


Cat. No.: EX-A12839	Purity: >98%

	Chemical structure of ZX782

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1g	get quote	Inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Purity	>98%
Formula	C39H48ClN5O8
Mol Weight	750.28
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Design, Synthesis, and Biological Evaluation of Hydrophobic-Tagged Glutathione Peroxidase 4 (GPX4) Degraders
CoA	CoA of ZX782

Smiles:	O=C(C1=NOC(C)=C1[N+]([O-])=O)N2CCN(C(C3=CC=C(OCCOCCOCC(NCC4(C[C@@H](C5)C6)C[C@@H]6C[C@@H]5C4)=O)C=C3)C7=CC=C(Cl)C=C7)CC2


		Search