ZX703

ZX703 (compound 5I) is a PROTAC that significantly degrades GPX4 in a dose- and time-dependent manner through the ubiquitin-proteasome and autophagy-lysosome pathways (DC50=0.315 µM). ZX703 induces ferroptosis by inducing Reactive Oxygen Species (ROS) accumulation in cells. ZX703 can be used for cancer research.


Cat. No.: EX-A10271	Purity: >98%

	Chemical structure of ZX703

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	2500	In-stock
500mg	get quote	In-stock
1g	get quote	Inquire

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Purity	>98%
Formula	C54H67ClN8O9S
Mol Weight	1039.676
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Mengdie Hu, et al. ZX703: A Small-Molecule Degrader of GPX4 Inducing Ferroptosis in Human Cancer Cells. ACS Med Chem Lett. 2024 Feb 15.
CoA	CoA of ZX703

Smiles:	O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCOC2=CC=C(C(C3=CC=C(Cl)C=C3)N4CCN(C(C5=NOC(C)=C5[N+]([O-])=O)=O)CC4)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6


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