Z62954982

Z62954982 (ZINC08010136) is a potent, selective and cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (IC50=50 μM). Z62954982 disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA).


Cat. No.: EX-A11026	Purity: >98%

	Chemical structure of Z62954982

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	500	In-stock
500mg	800	In-stock
1g	1385	In-stock
5g	5250	In-stock
10g	get quote	In-stock
25g	get quote

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Synonyms	ZINC08010136
CAS No.	1090893-12-1
Purity	>98%
Formula	C20H21N3O5S
Mol Weight	415.463
Color	White to off-white
State	Solid
Solubility	DMSO : 14.29 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Nicola Ferri,et al. Virtual Screening Approach for the Identification of New Rac1 Inhibitors. J Med Chem. 2009 Jul 23;52(14):4087-90. [2]. Xun E Zhang, et al. Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. PLoS One. 2016 May 17;11(5):e0155490. [3]. Min Yu, et al. Lack of BCR and Abr Promotes Hypoxia-Induced Pulmonary Hypertension in Mice. PLoS One
CoA	CoA of Z62954982

Smiles:	O=C(NC1=CC=C(C)C(S(=O)(N)=O)=C1)C2=CC=CC(OCC3=C(C)ON=C3C)=C2


		Search