YZ129

YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration.


Cat. No.: EX-A9418	Purity: >98%

	Chemical structure of YZ129

For research only, Do not use for Human!

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CAS No.	1643120-60-8
Purity	>98%
Formula	C19H12N2O2
Mol Weight	300.3108
Color	Brown to red
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Liu Z, et al. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8.
CoA	CoA of YZ129

Smiles:	O=C(C1=CC=CC=C1C(NC2=CC=C(C=NC=C3)C3=C2)=C4)C4=O


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