YY173

YY173 is a dual inhibitor for CDK4 and CDK6 with IC50 of 7.7 and 88 nM. YY173 inhibits the proliferation of cell Jurkat with an IC50 of 1.46 μM. YY173 can be used for synthesis of PROTAC CDK4/6 degrader 1 .


Cat. No.: EX-A17332	Purity: >98%

	Chemical structure of YY173

For research only, Do not use for Human!

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CAS No.	330550-51-1
Purity	>98%
Formula	C21H25N7O
Mol Weight	391.4695

Reference:	[1].He H, et al., Development of Degraders of Cyclin-Dependent Kinases 4 and 6 Based on Rational Drug Design. J Med Chem. 2024 Jul 11;67(13):11354-11364.
CoA	CoA of YY173

Smiles:	O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCNCC4)=NC=C2N=C1)C5CCCC5


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