YTR107

YTR107 is a radiation sensitizer. YTR107 binds to nucleophosmin1 (NPM1) and inhibits pentamer formation. YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppresses repair of DNA double strand breaks, and enhances radiosensitization .


Cat. No.: EX-A9795	Purity: >98%

	Chemical structure of YTR107

For research only, Do not use for Human!

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CAS No.	1207615-74-4
Purity	>98%
Formula	C21H14N4O3
Mol Weight	370.3609
Color	Light yellow to yellow
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sekhar KR, et al. The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization. Clin Cancer Res. 2011 Oct 15;17(20):6490-9. [2]. Traver G, et al. Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC. Cancer Lett. 2021 Mar 1;500:220-227.
CoA	CoA of YTR107

Smiles:	N#CC1=CC=C(C=C1)CN2C=C(C=C3C(=O)NC(=O)NC3=O)C=4C=CC=CC42


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