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Product Information:

YTHDC1-IN-1

YTHDC1-IN-1 is a selective YTHDC1 inhibitor with a Kd of 49 nM and an IC50 of 0.35 μM. YTHDC1-IN-1 can inhibit the proliferation and induce apoptosis of acute myeloid leukemia cell lines. YTHDC1-IN-1 has anti-tumor activity.

Cat. No.: EX-A12542    Purity: >98%
Chemical
Chemical structure of YTHDC1-IN-1


For research only, Do not use for Human!

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CAS No.2995344-53-9
Purity>98%
FormulaC13H11Cl2N5
Mol Weight308.166
ColorWhite to off-white
Statesolid
SolubilityDMSO : 25 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C 3 years; In solvent -20°C, 1 month.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. František Zálešák, et al. Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J Med Chem. 2024 Jun 13;67(11):9516-9535.

CoACoA of YTHDC1-IN-1
Smiles:ClC=1N=C(NC)C2=NNC(=C2N1)CC=3C=CC=C(Cl)C3

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