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Product Information:

YS43-22

MS4322 1 Publications Verification YS43-22 PROTACsHistone Methyltransferase Cancer MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer.

Cat. No.: EX-A6293    Purity: >98%
Chemical
Chemical structure of YS43-22


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10mg950Inquire
25mg1450Inquire
50mg2550Inquire
100mg3950Inquire


CAS No.2375432-47-4
Purity>98%
FormulaC55H76N10O12S
Mol Weight1101.317
Colorwhite to light yellow
Statesolid
SolubilitySoluble in DMSO 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Shen Y, et al. Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. J Med Chem. 2020 Sep 10;63(17):9977-9989.

CoACoA of YS43-22

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