YLIU-4-105-1

YLIU-4-105-1 is a Type II JAK2 inhibitor. YLIU-4-105-1 binds to the ATP-binding pocket of JH1. YLIU-4-105-1 has in vivo pharmacodynamic activity as evidenced by inhibiting pSTAT5, reducing spleen to body weight, and lowering blood reticulocyte counts in a dose-dependent manner.


Cat. No.: EX-A13510	Purity: >98%

	Chemical structure of YLIU-4-105-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	436	in-stock
25mg	785	in-stock
50mg	1250	in-stock
100mg	1985	in-stock
500mg	get quote	in-stock
1g	get quote	in-stock

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CAS No.	2417685-83-5
Purity	>98%
Formula	C32H34F3N7O2
Mol Weight	605.6533
Color	Off-white to light yellow
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Arwood ML, et al. New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation. Cell Chem Biol. 2023 Jun 15;30(6):618-631.e12.
CoA	CoA of YLIU-4-105-1

Smiles:	O=C(NC=1C=C(C=C(C1)C(F)(F)F)CN2CCN(CC)CC2)C=3C=CC(=C(C3)C4=NN5C=C(N=C5C=C4)NC(=O)C6CC6)C


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