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Product Information:

YKL-5-124

YKL-5-124 is a novel potent, selective, and covalent CDK7 inhibitor (IC50=53.5 nM), inhibits CDK7/CycH/MAT1 enzymatic activity with IC50 of 9.7 nM.

Cat. No.: EX-A5275    Purity: >98%
Chemical
Chemical structure of YKL-5-124


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg585In-stock
50mg785In-stock
100mg1185In-stock
200mg1785In-stock
500mg2585In-stock
1g3885In-stock


CAS No.1957203-01-8
Purity>98%
FormulaC28H33N7O3
Mol Weight515.6067
ColorWhite to off-white
Statesolid powder
SolubilitySoluble in DMSO 100 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Olson CM, et al. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 Jun 20;26(6):792-803.e10. doi: 10.1016/j.chembiol.2019.02.012.
CoACoA of YKL-5-124
Smiles:O=C(N(C1)C(C)(C)C2=C1C(NC(C3=CC=C(NC(C=C)=O)C=C3)=O)=NN2)N[C@@H](C4=CC=CC=C4)CN(C)C

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