YH-53

YH-53 is a potent 3CL Protease inhibitor wit Ki values of 6.3 nM, 34.7 nM for SARS-CoV-1 3CL Protease and SARS-CoV-2 3CL Protease, respectively. YH-53 strongly blocks the SARS-CoV-2 replication.


Cat. No.: EX-A5547	Purity: >98%

	Chemical structure of YH-53

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	950	In-stock
50mg	1600	In-stock
100mg	2785	In-stock

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CAS No.	1471484-62-4
Purity	>98%
Formula	C30H33N5O5S
Mol Weight	575.679
Color	Light yellow to green yellow
State	solid powder
Solubility	Soluble in DMSO 50 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sho Konno, et al. 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. J Med Chem. 2021 Jul27;acs.jmedchem.1c00665. [2].Pillaiyar Thanigaimalai, et al. Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: design, synthesis, biological evaluation, and docking studies. Eur J Med Chem. 2013 Oct;68:372-84.
CoA	CoA of YH-53


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