YF438

YF438 is an HDAC inhibitor with effective anticancer activity both in vitro and in vivo. YF438 inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2-MDMX, and promoting the degradation of MDM2.


Cat. No.: EX-A11681	Purity: >98%

	Chemical structure of YF438

For research only, Do not use for Human!

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CAS No.	2247210-09-7
Purity	>98%
Formula	C23H26N4O5
Mol Weight	438.4763
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Shan P, et al. Alteration of MDM2 by the Small Molecule YF438 Exerts Antitumor Effects in Triple-Negative Breast Cancer. Cancer Res. 2021 Aug 1;81(15):4027-4040.
CoA	CoA of YF438

Smiles:	O=C(NO)CCCCCC(=O)N(C1=CC=C(OC)C=C1)CC2=NOC(=N2)C=3C=CC=CC3


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