YF135

YF135 is an efficient and reversible-covalent KRASG12C PROTAC. YF135 significantly induces the degradation of KRASG12C in a reversible manner and decreases phospho-ERK level through the E3 ligase VHL mediated proteasome pathway.


Cat. No.: EX-A8037	Purity: >98%

	Chemical structure of YF135

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1mg	880	In-stock
5mg	2200	In-stock
50mg	get quote	Inquire

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CAS No.	2913177-53-2
Purity	>98%
Formula	C63H75ClN12O7S
Mol Weight	1179.864
State	solid powder
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yang F, Wen Y, Wang C, et al. Efficient targeted oncogenic KRAS^G12C degradation via first reversible-covalent PROTAC. Eur J Med Chem. 2022;230:114088.
CoA	CoA of YF135

Smiles:	CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCOCCCN4CCC[C@H]4COC5=NC6=C(CCN(C6)C7=CC=CC8=C7C(=CC=C8)Cl)C(=N5)N9CCN([C@H](C9)CC#N)C(=O)/C(=C/C1CC1)/C#N)O


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