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Product Information:

YDR1

YDR1 is a potent PROTAC SMARCA2 degrader, with the DC50 of 7.7 nM. YDR1 plays an important role in SMARCA4 mutant cancers.

Cat. No.: EX-A13244    Purity: >98%
Chemical
Chemical structure of YDR1


For research only, Do not use for Human!

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CAS No.2951015-31-7
Purity>98%
FormulaC44H49FN10O5
Mol Weight816.9223
ColorLight yellow to yellow
StateSolid
SolubilityDMSO : 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Sasikumar Kotagiri, et al. Discovery of Novel, Potent and Orally Bioavailable SMARCA2 PROTACs with Synergistic Anti-tumor Activity in Combination with KRAS G12C Inhibitors. bioRxiv [Preprint]. 2024 Aug 26:2024.08.23.608456.

CoACoA of YDR1
Smiles:O=C1C2=CC=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCN(CC4)CC5CCN(C6=CC=C(C=C6F)CN7CCN(C=8C=C(N=NC8N)C9=CC=CC=C9O)CC7)CC5

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