WX-02-43

WX-02-43 is a weak covalent inhibitor of SF3B1, and is the (1S,3R) enantiomer of WX-02-23 (HY-168534). WX-02-43 cannot effectively covalently modify the C258 site in the DNA-binding domain of FOXA1, and its inhibitory activity against SF3B1 is also weaker than that of WX-02-23. WX-02-43 serves as a negative control probe that fails to remodel the chromatin binding pattern and transcriptional activity of FOXA1. WX-02-43 can be used in studies on cancers such as prostate cancer to verify the specific effects of WX-02-23 on FOXA1 and SF3B1 targets .


Cat. No.: EX-A17445	Purity: >98%

	Chemical structure of WX-02-43

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	get quote	Inquire
10mg	get quote	Inquire
100mg	get quote	Inquire
500mg	get quote	Inquire
1g	get quote

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2929223-36-7
Purity	>98%
Formula	C26H25N3O5
Mol Weight	459.4938
Color	White to light yellow
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Won SJ, et al. Redirecting the pioneering function of FOXA1 with covalent small molecules. Mol Cell. 2024;84(21):4125-4141.e10. [2].Ng B W L, et al. Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics[J]. Molecular Cell, 2023, 83(10): 1544-1546. [3].Lazear MR, et al. Proteomic discovery of chemical probes that perturb protein complexes in human cells. Mol Cell. 2023;83(10):1725-1742.e12.
CoA	CoA of WX-02-43

Smiles:	C(C=C)(=O)N1[C@H](C2=C(C=3C(N2)=CC=CC3)C[C@@H]1C(=O)N4CCOCC4)C=5C=C6C(=CC5)OCO6


		Search