WRR139

WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer. WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells.


Cat. No.: EX-A9451	Purity: >98%

	Chemical structure of WRR139

For research only, Do not use for Human!

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CAS No.	2138924-36-2
Purity	>98%
Formula	C25H32N2O4S
Mol Weight	456.598
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tomlin FM, et al. Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity. ACS Cent Sci. 2017 Nov 22;3(11):1143-1155.
CoA	CoA of WRR139

Smiles:	O=C(NCCC(C)C)[C@@H](NC(/C=C/S(C1=CC=C(C)C=C1)(=O)=O)=O)CCC2=CC=CC=C2


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