WRN inhibitor 19

WRN inhibitor 19 (Compound 40) is a WRN helicase inhibitor (IC50: 3.7 nM). WRN inhibitor 19 exhibits selective antiproliferative activity in WRN-dependent cancer cells. WRN inhibitor 19 inhibits WRN helicase function by competitively binding to the ATP site and induces DNA damage and cell cycle arrest. WRN inhibitor 19 can be used in the study of WRN-dependent cancers.


Cat. No.: EX-A13295	Purity: >98%

	Chemical structure of WRN inhibitor 19

For research only, Do not use for Human!

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Purity	>98%
Formula	C40H52F4N6O6
Mol Weight	788.8711
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tong Y, et al. Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen. J Med Chem. 2025 Jun 5.
CoA	CoA of WRN inhibitor 19

Smiles:	CN(C([C@H](NC([C@@H]1CN(CC[C@@H]1NC(CCN2C(NC3=C2C=CC(CC(C)(O)C)=C3)=O)=O)C(CC4=CC=C(C=C4F)C(F)(F)F)=O)=O)CC5CCCCC5)=O)C


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