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Product Information:

WEHI-539 hydrochloride

WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with an IC50 of 1.1 nM.

Cat. No.: EX-A1595A    Purity: >98%
Chemical
Chemical structure of WEHI-539 hydrochloride


For research only, Do not use for Human!

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CAS No.2070018-33-4
Purity>98%
FormulaC31H30ClN5O3S2
Mol Weight620.185
ColorLight yellow to light brown
Statesolid powder
SolubilityDMSO : 16.67 mg/mL H2O : < 0.1 mg/mL
Shelf Life>3 years if stored properly
Storage4°C, sealed storage, away from moisture and light
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1].Lessene G, et al. Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol. 2013 Jun;9(6):390-7.

[2].Abed MN, et al. Antagonism of Bcl-XL is necessary for synergy between NSC 241240 and BH3 mimetics in ovarian cancer cells. J Ovarian Res. 2016 Apr 14;9:25.

CoACoA of WEHI-539 hydrochloride
Smiles:OC(C1=C(CCCOC2=CC=C(CN)C=C2)SC(C3=CC4=C(CCC/C4=N\NC5=NC(C=CC=C6)=C6S5)C=C3)=N1)=O.[H]Cl

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