WDR5 PROTAC MS40

MS40 is a WDR5 PROTAC degrader (Kd = 125 nM). MS40 promotes the ubiquitination and degradation of WDR5. MS40-induced WDR5 degradation leads to the dissociation of the MLL/KMT2A complex from chromatin, resulting in decreased H3K4me2 levels. MS40 can be used in the study of primary leukemia.


Cat. No.: EX-A13124	Purity: >98%

	Chemical structure of WDR5 PROTAC MS40

For research only, Do not use for Human!

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CAS No.	2407449-49-2
Purity	>98%
Formula	C52H61F3N10O7
Mol Weight	995.0987
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Li D, et al. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. 2022 Jun;41(24):3328-3340.
CoA	CoA of WDR5 PROTAC MS40

Smiles:	O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=CC(C3=CC=CC(CN4CCN(CCNC(CCCCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)CC4)=C3)=CC=C2N8CCN(C)CC8


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